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AM Biotech’s Patented Bio-Pulsed Exosomes

ExoGiov®

AM Biotech utilizes patented “Bio-Pulsed” technology to further produce over a hundred types of exosomes with various effects, which including for cosmetic hair growth, treating degenerative arthritis, accelerating fracture healing, treating premature ovarian failure, treating macular degeneration, treating tinnitus and hearing loss, and more.
The efficacy and quality of ExoGiov® Bio-Pulsed Exosomes are supported by solid scientific evidence. The research findings have been published in the prestigious International Journal of Molecular Sciences. This paper presents part of the patented “Bio Pulsed” technology developed by AM Biotech.
Through this technology, the number of exosomes secreted by stem cells can be increased by 93 times. Simultaneously, the content of proteins and miRNA within the exosomes also increased by 1.4 and 1.3 times respectively. Significantly increasing the quality and quantity of the exosomes.

The cellular experiments in the paper further demonstrate the various bioactivities and remarkable effects of the Bio-Pulsed Exosomes. Besides promoting the healing of skin cell wounds, the expression of key skin components related to hydration and elasticity, such as Type I collagen, Type III collagen, and elastin, also significantly increased. It was also verified that genes related to hair follicle cell activity and proliferation, such as RAC1, IGF-1, CCND1, PCNA, were significantly enhanced in experiments using Bio-Pulsed Exosomes on hair follicle cells. Those genes related to hair follicle cell apoptosis, CASP2, and TP53, were also inhibited.

Download White Paper

What is an Exosome?

Exosomes are a special type of extracellular nanovesicle, and they are nanosized and bioactive. We can consider them as the spokespersons for stem cells. Exosomes are capable of transferring information between different cells, and they also act as conductors coordinating intercellular operations, delivering a wealth of growth factors and anti-inflammatory agents, being responsible for the repair of organs and tissues, and regulating immune responses.
The paracrine and homing functions of exosomes positively affect the regeneration of damaged cells and inflammatory responses. Exosomes aid in the repair of our body’s cells and tissues. Recent years, understanding and applying exosomes has become crucial in regenerative medicine and medical aesthetics. Many diseases once thought irreversible, such as the repair of the nervous system (e.g., Alzheimer’s, stroke, glaucoma, etc.), the repair of organs (e.g., lungs, heart, kidneys, liver, etc.), as well as anti-aging and hair growth promotion, all have seen new hope through exosomes.

Technical advantages

AM BioTech specializes in the patented technology of bio-pulsed activation of stem cell exosomes, adeptly tailoring cell induction methods to specific demands and modifying exosome gene expression, with a dedicated team committed to the development and production of high-purity, high-quality induced bio-pulsed exosomes and related products for broad application in biopharmaceuticals, cancer diagnosis, scalp care, and medical aesthetics.

Patented Bio-Pulsed Activation Technology

Utilizing patented technology to construct a microenvironment library for stem cell exosome production can enhance the specific effects of the Bio-Pulsed Exosomes by tens of times. The number of exosome vesicle particles is 1900 times higher. The protein content within the exosomes increased by 202%. And the miRNA (=μARN) content within the exosomes increased by 188%.

Exosome Ultra-Purification Extraction Technology

With the high-efficiency exosome ultra-purification extraction technology developed by AM Biotech, producing induced Bio-Pulsed Exosomes that meet medical, cosmetic, and hair growth needs with a purity of up to 99.99%.

Advanced Mass Production Process

Exclusive mass production technology can increase the production volume by more than 30 times per unit time. The reconstituted induced Bio-Pulsed Exosome lyophilized powder whose diameter of exosome particles remains within 200nm and keep consistent particle size, intact structure, and stable activity and quality.

High-Efficiency Exosome Production Technology

The lyophilized powder and its reconstituted solution can withstand room temperature for 2 years and high temperatures of 60°C for three days in stress tests. Our Bio-Pulsed Exosome can be stored at room temperature and maintaining their activity and efficacy stably.

What advantages or characteristics do “Bio-Pulsed Exosomes” have compared to common exosomes?

  • Specific effects (such as beauty and hair health) are enhanced by tens of times.
  • Both liquid and powder forms can be preserved and transported at room temperature
  • The number of vesicle particles is 1900 times higher
  • Protein content is increased by 202%
  • miRNA content is increased by 188%

The Expression of miRNA and Their Role

Anti-aging

Whitening

Scar Removel / Anti-acne/ Wound healing

Smooth winkle

Hair growth

Targeting Specific miRNA for
Skin Beauty & Hair Growth

ExoGiov® Bio-Pulsed Exosome Efficacy Data

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